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Volume 23, Issue 12
Commentary from the Editorial Board
Free Access

Accelerating bleaching in vitiligo: balancing benefits versus risks

Julien Seneschal

Corresponding Author

Department of Dermatology and Pediatric Dermatology, National Centre for Rare Skin disorders, Hôpital Saint‐André, Bordeaux, France

INSERM U1035, Bordeaux University, Bordeaux, France

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Katia Boniface

INSERM U1035, Bordeaux University, Bordeaux, France

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First published:  18 July 2014
Cited by: 1

Abstract

While the goal of available treatment in vitiligo is to regain pigmentation, some patients affected by extensive and treatment‐resistant vitiligo, with a major social and emotional impact, may benefit from depigmentation therapy. However, results from such therapy may not always be satisfactory. So to achieve better, faster and complete bleaching, Webb et al. propose a synergistic approach that combines topical application of bleaching phenols which targets melanocytes and initiate local inflammation with immune adjuvants so as to obtain an enhanced immune response against remaining melanocytes. This strategy could be reliable, but should be evaluated cautiously in future studies, in terms of potential side effects and induction of undesired autoimmunity.

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